This wonder combination is a safe nutritional support for diabetes and its complications. In diabetes having a healthy diet (which includes mini-fasting) and exercising regularly are necessary to lower blood sugar levels. But nutritional support is also a key component because diabetes is a 'nutritional wasting disease' and most experts make no attempt to replace the losses and allow their patients to overcome the nutritional deficiencies. Elevated glucose levels act like a diuretic and cause substantial loss of nutrients in the urine. Therefore, people with type 2 diabetes are likely to be deficient in important water-soluble vitamins and minerals. A second reason nutritional supplements for diabetes are essential is that carefully increasing your intake of nutrients that support your body's ability to use insulin can help keep your blood sugar at healthy levels and its associated complications.

Indications:
●Helps maintain blood sugar level
●In diabetic & peripheral neuropathy
●Supports metabolism & growth
●Protect eyes, kidneys, nerves & blood vessels from damage
●In diabetic ulcers & periodontal disease

About Combination:

Berberine:
Berberine, a plant alkaloid revered in traditional Chinese and Ayurvedic medicine is poised to become one of the most powerful natural therapies useful in a wide range of conditions - particularly insulin resistance and diabetes.

What Conditions is Berberine Good For?
●Anti-aging
●Diabetes
●Heart disease
●High cholesterol
●Hypertension (high blood pressure)
●Immune challenges
●Intestinal infections
● Joint problems
● Low bone density
●Weight control

How Does Berberine Work?
Berberine targets a very basic and ancient regulator of metabolism called AMP-activated protein kinase (AMPK). Increased AMPK activity explains why berberine has so many diverse benefits.
For people with diabetes, AMPK activation: 
● Stimulates the uptake of glucose into the cells
● Improves insulin sensitivity
● Reduces glucose production in the liver
The researchers concluded, "In summary, berberine is a safe, potent oral hypoglycemic [blood sugar lowering] agent with modest effect on lipid metabolism, blood pressure and weight.
As per in comparative study with metformin, berberine exhibited an identical effect in the regulation of glucose metabolism, such as HbA1c, FBG [fasting blood glucose], PBG [blood sugar after eating], fasting insulin and postprandial insulin [insulin level after eating]. In the regulation of lipid metabolism, berberine activity is better than metformin. Triglycerides and total cholesterol in the berberine group had decreased and were significantly lower than in the metformin group.

Purslane:
Purslane (Portulaca oleracea) is a plant is useful in diabetes by lowering blood sugar naturally.

How Does Purslane Work to Lower Blood Sugar Naturally?
●Increases insulin sensitivity
●Enhances glucose uptake into the cells
● Slows the transport of glucose from the intestines into the bloodstream
●Lowers hemoglobin A1c
Along with its properties for lowering blood sugar naturally, animal studies suggest that purslane also curbs appetite and assists in weight loss.

Gymnema sylvestre:
Gymnema Sylvestre extract derives from the leaves of a climbing plant native to the forests of central and south India. It is effective in natural treatment for diabetes.

How Does Gymnema Sylvestre Extract Work?
The leaves of the Gymnema Sylvestre plant contain gymnemic acids, which have been slow the transport of glucose from the intestines to the bloodstream. This, in turn, helps to:
●Lowers blood sugar
●Lowers hemoglobin A1c

Banaba Leaf Extract:
Banaba leaf extract (Lagestroemia speciosa), which comes from Asia, is another herbal extract worth adding to your arsenal. This herb contains corosolic acid, which promotes glucose transport into cells, keeping blood sugar on an even keel.
It can inhibit uptake (digestion and absorption) of carbohydrates to a degree, and can also aid in their deposition into cells from the blood stream (resulting in a reduction in blood sugar).

B-Complex Vitamins:
One of the potential side effects of diabetes is neuropathy, or nerve damage. It is caused by high blood glucose over a long period. The most common symptoms of diabetic neuropathy are numbness, weakness, and pain in the hands and feet. This is called peripheral neuropathy. It can also affect other body parts, including the gastrointestinal tract. Vitamins B₆ and B₁₂ specifically support nerve health, which is critical for addressing conditions such as diabetic neuropathy.
Biotin is another B-complex vitamin that is necessary for both metabolism and growth. Biotin is also involved in the manufacture and utilization of protein, fats and carbohydrates.

Vitamin C:
Research shows that vitamin C may have protective effects against diabetes. Diabetes is a disease marked by a good amount of oxidative damage- damage done to your cells and DNA by rogue molecules called free radicals. Antioxidants- like vitamin C- can help protect against this.
Vitamin C also lowers levels of sorbitol, the sugar that can collect in and damage cells in the eyes, kidneys and nerves.

Vitamin D:
The association of low serum 25-hydroxyvitamin D₃ [25(OH)D₃] concentrations with type 2 diabetes may be mediated through effects on glucose homeostasis and, in particular, a direct effect of vitamin D on the β-cell function, and thus insulin secretion. Several studies have suggested that low vitamin D status also contributes to insulin resistance. Low vitamin D status is associated with markers of impaired glucose metabolism, such as glycosylated hemoglobin (HbA_1c).
 Vitamin D replenishment improves glycaemia and insulin secretion in patients with type 2 diabetes with established hypovitaminosis D, thereby suggesting a role for vitamin D in the pathogenesis of type 2 diabetes mellitus. 
The mechanism of action of vitamin D in type 2 diabetes is thought to be mediated not only through regulation of plasma calcium levels, which regulate insulin synthesis and secretion, but also through a direct action on pancreatic beta-cell function.
Vitamin D turns on genes that boost production of antimicrobial peptides called cathelicidins, which destroy viruses, bacteria and other germs. Because people with diabetes are more prone to infections due to diabetic ulcers and periodontal disease, making sure your body has optimal levels of this fat-soluble vitamin is important.

Vitamin E:
Vitamin E is the body's premier fat-soluble antioxidant. It improves control and protects blood vessels and nerves from free radical damage, which is accelerated by the diabetes. Studies have shown that high doses of supplemental vitamin E may even reverse damage to nerves caused by diabetes and protect against diabetic cataracts and atherosclerosis.

Magnesium:
Magnesium is a mineral crucial for energy production and protein cellular replication and DNA production. Magnesium has also been shown to decrease insulin resistance, helping to keep blood sugar levels in check.
The health benefits of magnesium supplements are even more important if you already have diabetes. Diabetes is a nutritional wasting disease. When blood sugar is high, it becomes a powerful diuretic that leads to increased urination. Unfortunately, this results in losses of virtually all water-soluble nutrients, leading to deficiencies in a number of vitamins and minerals—including magnesium.
This is problematic because low magnesium levels not only make controlling blood sugar more difficult but also increase risk of diabetic complications. For example, studies show that individuals with the lowest levels of magnesium are the most likely to have severe diabetic retinopathy.

Side Effects:
Common side-effects include:
●Headache
●Diarrhoea
●Nausea
●Fatigue or weakness

Precautions:
●Do not take, if you are sensitive to any of its ingredients.
●Always check with your doctor before taking vitamin E supplements. Vitamin E may increase the risk of bleeding, especially if you are taking blood-thinners such as warfarin, aspirin, or clopidogrel.

Storage:
Store in cool and dry place.